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Cell proliferation and DNA replication defects in a Drosophila MCM2 mutant.
Treisman JE, Follette PJ, O'Farrell PH, Rubin GM.
Howard Hughes Medical Institute, University of California, Berkeley 94720, USA.
The
yeast MCM2, MCM3, and MCM5/CDC46 genes are required for DNA replication
and have been proposed to act as factors that license the DNA for one
and only one round of replication per cell cycle. We have identified a
Drosophila gene, DmMCM2, that is highly homologous to MCM2. A P-element
insertion into this gene, which prevents its transcription, inhibits
proliferation of cells in the imaginal discs and central nervous system
(CNS) and causes an apparent prolongation of S phase in the embryonic
and larval CNS. DmMCM2 is expressed in the embryo in a pattern
corresponding to that of S-phase cells. These results suggest that
DmMCM2 plays a role in the regulation of DNA replication analogous to
that of its yeast counterpart.
PMID: 7622035 [PubMed - indexed for MEDLINE]
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